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Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that as of right now there aren't long term prescription diet pills that have been authorized by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and must not be taken in people with seizure disorders. The drug can also raise blood pressure level and heartrate, and mustn't be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must not used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. 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